Journal: Materials Today Bio

Article Title: Harnessing the dual immunomodulatory function of myeloid-derived suppressor cells to reshape the inflammatory microenvironment for osteoarthritis therapy

doi: 10.1016/j.mtbio.2025.102332

Figure Lengend Snippet: The schematic diagram illustrating the preparation and mechanism of action of immune-regulatory hydrogel microspheres for the treatment of osteoarthritis (HAMA-MSN@TGF-β1/Anti-IL-1β): Mesoporous silica nanoparticles (MSNs) encapsulating anti-IL-1β and TGF-β1 are incorporated into hyaluronic acid (HAMA) microspheres and in situ injected into the joint cavity. The anti-IL-1β effectively blocks MDSC-mediated differentiation of Th17 cells, resulting in the downregulation of the inflammatory response driven by IL-17. Furthermore, the presence of TGF-β1 promotes the polarization of macrophages toward the M2 phenotype and facilitates cartilage regeneration. This collective action leads to a transition of the osteoarthritis microenvironment from an inflammatory state to a regenerative state.

Article Snippet: Mesoporous silica nanoparticles (size: 100 nm, pore diameter: 3–4 nm) were purchased from Ruixi Biotech Co.Ltd.

Techniques: In Situ, Injection